DAMUDE, HOWARD G.,MACOOL, DANIEL JOSEPH,PICATAGGIO, STEPHEN K.,RAGGHIANTI, JAMES JOHN,XUE, ZHIXIONG,YADAV, NARENDRA S.,ZHANG, HONGXIANG,ZHU, QUINN QUN,POLLAK, DANA M. WALTERS
申请号：
DK12152258
公开号：
DK2458000T3
申请日:
2005.11.03
申请国别(地区):
DK
年份:
2013
代理人:
摘要：
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 10% arachidonic acid (ARA, an É-6 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases, and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of ARA. Production host cells are claimed, as are methods for producing ARA within said host cells.
