Provided is a composition for heat melt extrusion which contains at least a medicament and a hypromellose acetate succinate (HPMCAS) that has a degree of molar substitution of hydroxypropoxy groups of 0.40 or more and a ratio (molar ratio) of acetyl groups to succinyl groups of less than 1.6. Also provided is a method for producing a heat melt extruded product which comprises at least a step wherein a composition for heat melt extrusion containing at least a medicament and a hypromellose acetate succinate that has a degree of molar substitution of hydroxypropoxy groups of 0.40 or more and a ratio (molar ratio) of acetyl groups to succinyl groups of less than 1.6 is heated melted and extruded at a heat melt temperature that is not less than the melting temperature of the hypromellose acetate succinate or not less than the temperature at which both the hypromellose acetate succinate and the medicament are melted.
