PROBLEM TO BE SOLVED: To provide a pharmaceutical, a quasi drug, a food product, feed and a material which can be blended therewith, having excellent PDE3 inhibitory action and a high level of safety.SOLUTION: This invention comprises (A) Origanum majorana L., Petroselinum crispum, Glycyrrhiza L. and extracts thereof, and (B) one or more selected from the group consisting of &bgr;-carotene as an active ingredient.