您的位置: 首页 > 农业专利 > 详情页

Method for manufacturing a pharmaceutical composition in the form of extended-release tablets containing Pirfenidone and use thereof in the regression of chronic renal insufficiency, breast capsular contracture and hepatic fibrosis in humans
专利权人:
Cell Therapy and Technology S. A. de C.V.
发明人:
Armendariz Borunda, Juan,Magana Castro, Jose Agustin Rogelio,Cervantes Guadarrama, Jorge
申请号:
AU2012284627
公开号:
AU2012284627A8
申请日:
2012.07.13
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
The present invention relates to a method for manufacturing a pharmaceutical composition in the form of extended-release tablets that include from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), such that the drug containing same is bioavailable during an extended period of 12 hours from the administration thereof. This optimizes the anti-fibrotic and anti-inflammatory action of the Pirfenidone. Additionally, the present invention offers advantages and better therapeutic effectiveness over other pharmaceutical forms of Pirfenidone for oral administration and the therapeutic use thereof in the regression of chronic secondary renal insufficiency to primary glomerulosclerosis; it shows greater activity in the decrease and/or regression of the toxic effects on the breast capsular contracture observed after surgical implantation of breast implants in humans and exercises a significant anti-TNF-α and anti-TGF-βΙ action in the treatment of hepatic fibrosis.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充