METHOD FOR MANUFACTURING A PHARMACEUTICAL COMPOSITION IN THE FORM OF EXTENDED RELEASE TABLETS CONTAINING PIRFENIDONE AND USE THEREOF IN THE REGRESSION OF CHRONIC RENAL INSUFFICIENCY BREAST CAPSULAR CONTRACTURE AND HEPATIC FIBROSIS IN HUMANS
ARMENDARIZ BORUNDA JUAN,MAGAÑA CASTRO José Augustin Rogelio,CERVANTES GUADARRAMA JORGE
申请号：
IN415/DELNP/2014
公开号：
IN2014DN00415A
申请日:
2014.01.17
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to a method for manufacturing a pharmaceutical composition in the form of extended release tablets that include from 600 milligrams to 2400 milligrams of Pirfenidone (PFD) such that the drug containing same is bioavailable during an extended period of 12 hours from the administration thereof. This optimizes the anti fibrotic and anti inflammatory action of the Pirfenidone. Additionally the present invention offers advantages and better therapeutic effectiveness over other pharmaceutical forms of Pirfenidone for oral administration and the therapeutic use thereof in the regression of chronic secondary renal insufficiency to primary glomerulosclerosis it shows greater activity in the decrease and/or regression of the toxic effects on the breast capsular contracture observed after surgical implantation of breast implants in humans and exercises a significant anti TNF a and anti TGF ß? action in the treatment of hepatic fibrosis.
