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BIFLUORODIOXALANE-AMINO-BENZIMIDAZOLE KINASE INHIBITORS FOR THE TREATMENT OF CANCER, AUTOIMMUNEINFLAMMATION AND CNS DISORDERS
专利权人:
4SC DISCOVERY GMBH
发明人:
Leban, Johann,Лебан Йоханн,Zaja, Mirko,Зая Мірко
申请号:
UA201500560
公开号:
UA116541C2
申请日:
2013.06.27
申请国别(地区):
UA
年份:
2018
代理人:
摘要:
The invention relates to a compound of the general formula (I) or a physiologically functional derivative, solvate or salt thereof, (I) wherein A is a bond, alkyl or alkoxy optionally substituted with one or more R’’ as defined herein, *-N(R’’’)CO-, *-CON(R’’’)-, *-N(R’’’)CON(R’’’)-, -S-, -SO-, *-N(R’’’)-, *-N(R’’’)CO-, *-CON(R’’’)-, -CO-, *-COO-, *-OOC-, *-SO2N(R’’’)-, -SO2, or *-N(R’’’)-SO2-, wherein R’’’ is as defined herein and * specifies the point of attachment to X X is aryl, cycloalkyl, aralkyl, heterocyclyl or heteroaryl, which may be substituted with one or more Rx further described herein L is a bond or *-N(RN)CO-, *-CON(RN)-, *-N(RN)-, *-C=N(RN)-, *-N(RN)-alkyl-, *-alkyl-N(RN)-, *-N(RN)CON(RN)-, *-CO-, *-SO2-, alkyl, *-alkyl-0-alkyl-, *-NCO-CH=CH-, *-CH=CH-CONH-, * -SO2N(RN)-, *-N(RN)SO2-, or heterocyclyl, wherein * specifies the point of attachment to X Y is H, alkyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heteroaryl, which may be substituted with one or more RY further described herein and R and RN are further described herein as well as their use as a medicament, a pharmaceutical composition comprising them, a method of treatment or prevention of a medical condition entailing the administration thereof, and the use thereof in the manufacture of a medicament for the treatment or prevention of a medical condition, particularly autoimmune inflammatory disorders, CNS disorders, sleeping disorders, or proliferative diseases including cancer. The invention further relates to a specific process for the preparation of said compounds.Даний винахід стосується сполуки загальної формули (І) або її фізіологічно функціональної похідної, сольвату або солі: EMBED ISISServer , (I) де А являє собою звязок, алкіл або алкокси, необовязково заміщений одним або декількома R", визначеними у даному документі, *-N(R)CO-, *-CON(R)-, *-N(R)CON(R)-, -S-, -SO-, *-N(R)-, *-N(R)CO, *-CON(R)-, -CO-, *-COO-, *-OOC-, *-SO2N(R)-, -SO2 або *-N(R)-SO2-, де R визначений у даному докум
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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