BRADNER JAMES ELLIOT,TANG WEIPING,SCHREIBER STUART L.,MAZITSCHEK RALPH
申请号:
IN3512/KOLNP/2008
公开号:
IN272514B
申请日:
2008.08.28
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.