Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of using the compounds to treat diseases during which NAMPT is expressed, e.g., cancer, metabolic disorders, and inflammatory disorders. Disclosed are 1,3-dihydro-2H-isoindole compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of using the compounds to treat diseases during which ROCK is expressed, e.g., cancer, cardiovascular disorders, and inflammatory disorders.La présente invention concerne des composés de formule (1c) qui inhibent l'activité de NAMPT, des compositions contenant les composés et des procédés de traitement de maladies dans lesquelles NAMPT est exprimé. La présente invention concerne des composés qui inhibent l'activité de ROCK, des compositions contenant les composés et des procédés de traitement de maladies dans lesquelles ROCK est exprimé.
