A quick lock and release clamp mountable onto the bedrail of an operating table, hospital bed, and the like. The clamp includes a body, a foot, and a mouth having at least three sides defined by the body and foot. A biasing member is coupled to at least one of the body and the foot, wherein an actuating member coupled to the biasing member is configured to transmit a force to the mouth via the biasing member. A protrusion extending from the body and towards the foot engages the bedrail, thereby fixing the clamp onto the bedrail, by moving the actuating member in a first direction.