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Method for identifying membrane Ig-specific antibodies and use for targeting precursor cells producing immunoglobulins
专利权人:
メディミューン,エルエルシー;メディミューン,エルエルシー
发明人:
ウー,ヘレン,キーナー,ピーター,チョードリー,パーサ,エス.,ヤング,ジェームス,エフ.,ウー,ヘレン,キーナー,ピーター,チョードリー,パーサ,エス.,ヤング,ジェームス,エフ.
申请号:
JP2008533581
公开号:
JP5389442B2
申请日:
2006.09.28
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored IgE and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of IgE-mediated diseases. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of IgE-mediated diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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