Peter Kiener;Herren Wu;James F. Young;Partha S. Chowdhury
发明人:
Herren Wu,Peter Kiener,Partha S. Chowdhury,James F. Young
申请号：
US13372170
公开号：
US08404236B2
申请日:
2012.02.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored immunoglobulins and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells.
