OSTEOBLAST DIFFERENTIATION PROMOTER HAVING AURAPTENE ANALOGOUS COMPOUND AS ACTIVE INGREDIENT, PHARMACEUTICAL COMPOSITION FOR OSTEOGENESIS PROMOTION AND HEALTH FUNCTIONAL FOODS
PROBLEM TO BE SOLVED: To provide a highly safe and effective osteoblast differentiation promoter, a pharmaceutical composition for osteogenesis promotion, health functional food, or the like.SOLUTION: There are provided an osteoblast differentiation promoter made of auraptene expressed in formula 1 or an analogous coumarin compound thereof, and a pharmaceutical composition for osteogenesis promotion and a health functional food in which the compound is blended. [R1 and R3 severally denote independently H, a hydroxy group, a methoxy group, a methyl group, an ethyl group, a propyl group, a carboxyl group, a carboxymethyl group or a carboxyethyl group； R2 denotes H, a hydroxy group, a methoxy group, a methyl group, an ethyl group, a propyl group, a carboxyl group, a carboxymethyl group, a carboxyethyl group or a coumarinyl group； R4 denotes a hydrogen atom, a straight-chain/branched-chain alkyl group having carbon number 1 to 15, an alkenyl group, an alkadienyl group or an alkatrienyl group]SELECTED DRAWING: None【課題】安全性及び有効性が高い骨芽細胞分化促進剤、骨形成促進用医薬組成物及び保健機能食品等の提供。【解決手段】式１で表されるオーラプテン又はその類縁クマリン類化合物からなる骨芽細胞分化促進剤及び該化合物を配合した骨形成促進用医薬組成物及び保健機能食品。［Ｒ１及びＲ３は各々独立にＨ、水酸基、メトキシ基、メチル基、エチル基、プロピル基、カルボキシル基、カルボキシメチル基又はカルボキシエチル基；Ｒ２はＨ、水酸基、メトキシ基、メチル基、エチル基、プロピル基、カルボキシル基、カルボキシメチル基、カルボキシエチル基又はクマリニル基；Ｒ４は、水素原子、炭素数１～１５の直鎖／分岐鎖のアルキル基、アルケニル基、アルカジエニル基又はアルカトリエニル基］【選択図】なし
