DR SURESH D JAGTAP,MISS PALLAVI S NIRMAL,DR ABHAY M HARSULKAR,MISS BHAGWASHRI E NAGARKAR,MRS AARTI N NARKHEDE,DR OMKAR P KULKARNI,PROF PRABHAKAR K RANJEKAR
申请号：
IN2509/MUM/2014
公开号：
IN2014MU02509A
申请日:
2014.08.05
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Osteoarthritis (OA) is one of the most commonly occurring degenerative diseases amongst the elderly population in the world (Peat et ai, 2001), that reflects the imbalance between destruction and repair mechanism of cartilage tissue, bone, synovium, joint capsule, ligaments, tendons and muscles (Little and Fosang, 2010, Boyan et ah, 2013). OA is considered to be the 4th leading cause of "years lived with disability" (World Health Organisation, 2006). It imposes a global burden of around 1 - 2.5% of total gross national products (Xie et al., 2008). The incidence of OA is on rise and is estimated to affect more than 25% of the adult U.S. population by 2030 (Hootman and Helmick, 2006). A number of drugs like analgesics, non-steroidal antiinflammatory drugs (NSAIDs) are referenced as useful agents in the management of OA but no drug has been able to satisfy both efficacy and safety (Zhang et al., 2008), It is an established fact that current available treatments for OA are associated with several side effects (Huh et al., 2008). Thus, it is imperative to explore traditional systems of medicine for a potential drug that may help to reduce inflammation, protect cartilage damage, offer relief from disease symptoms and restore patient activity levels and improve joint functions. Medicinal herbs have been effectively used for their anti-inflammatory activity, but their exact role has not yet been documented in scientific literature for the management of OA. The prior art studies in our lab have shown the efficacy of such herbs, which have been widely used in traditional medicine to treat arthritis in which we have tested comparative anti-osteoarthritic potential of Sida cordifolia L., Piper longum L,, Zingiber officinale Rose, Ricinus communis L., Vitex negundo L. and Tribulus terrestris L. using collagenase type II-induced osteoarthritis (CIOA) rat model. On the basis of results obtained, we have developed a new formulation using specific combination of effective herbs to e
