Ann and Robert H. Lurie Children's Hospital of Chicago
发明人:
Chandra Shekhar Mayanil,Elise Allender,Takao Tsurubuchi,Norman Ginsberg,David G. McLone,Tadanori Tomita
申请号：
US14331410
公开号：
US20150025008A1
申请日:
2014.07.15
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention generally relates to compositions, reagents and methods for detecting and treating a neural tube defect in a fetus. One aspect of the invention provides a method including administrating a composition containing noggin or LDN-193189 to the fetus in utero. In certain embodiments, the composition is administrated if the maternal blood or amniotic fluid contains an elevated amount of BMP4 and/or a reduced amount of noggin. In another aspect of the invention, the method includes administrating a composition containing GDC-0449 to the fetus in utero. In certain embodiments, the GDC-0449 is administrated if the maternal blood or amniotic fluid contains an elevated amount of sonic hedgehog.
