Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta sheet breaker moiety derived from alpha aminoisobutyric acid (Aib) are disclosed. The didpeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation as compared to previously described dipeptides. Compositions containing the didpetide analogs and uses thereof in treating amyloid associated diseases and disorders are also disclosed.
