MERZ PHARMA GMBH & CO. KGAA;RAMOT AT TEL-AVIV UNIVERSITY LTD
发明人:
ANAT FRYDMAN-MOROM,EHUD GAZIT,LUDIMILA BUZHANSKY,ULRICH ABEL,YANIV AMIR
申请号：
BR112013012033
公开号：
BR112013012033A2
申请日:
2011.11.15
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The didpeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the didpetide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.
