Orthodontic assemblies and related methods are provided where an adhesive coated orthodontic appliance is received in a container that includes a substrate and a lid having a retaining member. When the lid is closed, the retaining member is complemental to the shape of the appliance and engages with the appliance. By conforming to the shape of the appliance, the retaining member constrains the appliance from shifting in lateral and vertical directions within the container. When the lid is opened, the associated retaining member disengages from the appliance, thereby facilitating user access to the appliance.