Virginie Van Scherpenzeel Thim;Patrick Rheault;Ventzislav B. Vassilev;Normand Blais
发明人:
Ventzislav B. Vassilev,Virginie Van Scherpenzeel Thim,Normand Blais,Patrick Rheault
申请号：
US13378402
公开号：
US08889146B2
申请日:
2010.06.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present disclosure provides immunogenic compositions that include at least two paramyxovirus F protein antigens selected from human metapnuemovirus (hMPV), paarainfluenza virus (PIV) and respiratory syncytial virus (RSV). The antigens of the disclosed compositions are recombinant F protein polypeptides, which have been modified to stabilize the trimeric prefusion conformation. Nucleic acids encoding the antigens, as well as methods for their production and use are also provided.
