A dual chamber combined container-syringe includes: an outer casing having a bypass portion a hub lure lock a front stopper a middle stopper that seals a pharmaceutical preparation together with the front stopper an end stopper that seals a liquid medicine together with the middle stopper a finger grip and a plunger rod that is connected to the end stopper from the rear end side, wherein a female screw portion twisted around an axis is formed on an inner peripheral surface of the finger grip, and a first male screw portion, a tip of which comes into contact with a rear end of the female screw portion and can be screwed into the female portion, and a first guide plate are formed on an outer peripheral surface of the plunger rod when a part of the middle stopper enters the bypass portion.