Metal-organic frameworks for drug delivery systems, therapeutic compositions including the metal-organic frameworks, and method of treating cancer using the therapeutic compositions are disclosed. According to some embodiments, a method of treating cancer in a mammal may include: providing a therapeutic composition containing a nanocarrier with a drug-loaded metal organic framework； delivering the therapeutic composition to the mammal； allowing the nanocarrier to circulate throughout a circulatory system of the mammal for a time sufficient to allow aggregation of a therapeutic quantity of the nanocarrier at a treatment area； and applying ultrasound to the treatment area such that the nanocarrier releases the drug in the treatment area.
