Refers to a process for the preparation of a compound from Blood that is carried out in a Closed System, and that includes: a) a First Blood in a closed container with a pressure lower than atmospheric pressure and may optionally contain an anticoagulant b) Separating R The Blood by sedimentation or centrifugation into fractions of red blood cells.A fraction of white blood cells and platelets, and another fraction of plasma.The decreasing gradient towards the upper part of the first container (c) introduce a Extraction Device to the upper level of the highest fraction of First container (d) perform the steps to connect the device to a Second Container closed Vacuum extraction With a pressure lower than the first Container so that the amount of plasmaWhite blood cells with platelets and red blood cells are transferred to the second Container by pressure Difference wherein the second Container contains a procoagulant or a coagulating Agent, Activating Agent prior to the transfer from the first Container or added later. This procedure reduces the risk of contamination of the final CompoundSE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE UN COMPUESTO A PARTIR DE SANGRE QUE SE REALIZA EN UN SISTEMA CERRADO Y QUE COMPRENDE: A) DISPONER DE SANGRE EN UN PRIMER CONTENEDOR CERRADO CON UNA PRESION MENOR A LA PRESION ATMOSFERICA Y OPCIONALMENTE PUEDE CONTENER UN ANTICOAGULANTE B) SEPARAR LA SANGRE SEA POR SEDIMENTACION O CENTRIFUGACION EN FRACCIONES DE GLOBULOS ROJOS, UNA FRACCION DE GLOBULOS BLANCOS Y PLAQUETAS, Y OTRA FRACCION DE PLASMA, SIENDO EL GRADIENTE DECRECIENTE HACIA LA PARTE SUPERIOR DEL PRIMER CONTENEDOR C) INTRODUCIR UN DISPOSITIVO DE EXTRACCION HASTA EL NIVEL SUPERIOR DE LA FRACCION MAS SUPERIOR DEL PRIMER CONTENEDOR D) REALIZAR LOS PASOS DE CONECTAR AL DISPOSITIVO DE EXTRACCION UN SEGUNDO CONTENEDOR CERRADO AL VACIO CON UNA PRESION MENOR A LA DEL PRIMER CONTENEDOR PARA QUE LA CANTIDAD DE PLASMA, GLOBULOS BLANCOS CON PLAQUETAS Y GLOBULOS ROJOS SE TRANSFIERAN A
