The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e.g., ovarian cancer or pancreatic cancer). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment thereof that specifically binds to programmed death 1 (PD-1) receptor in combination with a therapeutically effective amount of a bispecific antibody that specifically binds Mucin 16 (MUC16) and CD3.本發明提供用於治療、減輕嚴重度或抑制癌症(例如卵巢癌或胰臟癌)之生長的方法。本發明之方法包括向有需要之個體投與治療有效量之計劃性死亡1(PD-1)受體的抗體或其抗原結合片段，其與治療有效量之特異性結合黏蛋白16(MUC16)及CD3之雙特異性抗體組合。
