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Thienopyrimidine derivative
专利权人:
ASKA PHARMACEUTICAL CO.; LTD.
发明人:
GOTANDA, KOTARO,SHINBO, ATSUSHI,NAKANO, YOUICHI,KOBAYASHI, HIDEO,OKADA, MAKOTO,ASAGARASU, AKIRA
申请号:
ES06766867
公开号:
ES2526701T3
申请日:
2006.06.13
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Thienopyrimidine derivatives represented by the following formula (I) ** formula ++ in which R1 represents hydrogen, C1-6 alkyl, C1-6 alkoxy C1-6 alkyl or C1-6 haloalkyl containing 1-6 halogen atoms, R2 represents hydrogen, C 1-6 alkyl, C 1-6 phenylalkyl or amino, R 3 represents C 2-6 alkyl, C 2-6 alkenyl, C 1-6 carbamoylalkyl, C 1-6 aminoalkyl, C 1-6 alkyl-C 1-6 amino, di- (alkyl C1-6) C1-6 aminoalkyl, C1-6-thio alkyl or group YX, or R2 and R3 can together form tetramethylene, X represents a direct bond or CH2, CH (OH), CH (C6H5), CO, CH2CH2, CH2CO, COCH2, S, O or NH and Y represents aromatic carbocyclic group, aromatic heterocyclic group, 4-7 membered cycloalkyl group, 4-7 membered cycloalkenyl group, saturated 5-7 membered heterocyclic group containing 1 or 2 atoms of nitrogen or saturated 5-7 membered heterocyclic group that forms a fused ring with a saturated 5 or 6 membered cyclic group and containing 1 or 2 atoms of nitrogen, where all these groups optionally contain 1-3 substituents selected from halogen atom, C 1-6 alkyl, C 1-6 haloalkyl containing 1-6 halogen atoms, C 1-6 haloalkyl containing 1-6 halogen atoms , C1-6-thio haloalkyl containing 1-6 halogen atoms, C1-6 alkoxy, C1-6-thio alkyl, C1-4-dioxy alkylene, carboxyl, C1-6-alkoxycarbonyl, oxo, amino, nitro and phenyl, Z represents S or O, and n is O or an integer from 1-4, provided that a case where R1 is methyl, R2 is hydrogen, R3 is benzyl, Z is O and n is 0, or salts is excluded of derivatives.Derivados de tienopirimidina representados por la siguiente fórmula (I)**fórmula++ en la que R1 representa hidrógeno, alquilo C1-6, alcoxi C1-6 alquilo C1-6 o haloalquilo C1-6 que contiene 1 - 6 átomos de halógeno, R2 representa hidrógeno, alquilo C1-6, fenilalquilo C1-6 o amino, R3 representa alquilo C2-6, alquenilo C2-6, carbamoilalquilo C1-6, aminoalquilo C1-6, alquil C1-6-amino C1-6, di-(alquil C1- 6)aminoalquil C1-6, alquil C1-6-tio o grupo Y-X, o R2 y R3 pueden formar juntos tetrametileno, X representa un
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