Fluid delivery systems, methods and devices for delivering a therapeutic fluid to the body of the patient are disclosed. A fluid delivery device (100) for delivering fluid to the body of the patient includes a housing having an upper wall (534) and a lower wall (536), wherein the upper wall includes an upper opening (116) and the lower wall includes a lower opening (540), a well-arrangement mechanism (510) configured to be disposed inside the housing and between the upper wall and the lower wall and including a tubular member (322) having a bore (326), wherein the bore is configured to be disposed between the upper opening and the lower opening, and a penetrating cartridge (662) for delivery of therapeutic fluid to the body of the patient, wherein the penetrating cartridge is configured toengage the bore following its insertion through the upper opening and the lower opening, wherein therapeutic fluid is configured to be delivered through the tubular member into the penetrating cartri dge into the body of the patient when the penetrating cartridge engages the bore.
