The present invention is directed to a novel method for treating or preventing systemic inflammation in a subject. The method administering to the subject a therapeutically effective amount of inactivated LGG.本發明係針對用於治療或預防個體之全身性發炎的新穎方法。該方法投給個體治療上有效量之去活化的鼠李醣乳酸桿菌GG(LGG)。