Dennis, Mark,Watts, Ryan Jefferson,Yu, Yunhua Joy,Zhang, Yin
申请号：
NZ72434811
公开号：
NZ724348A
申请日:
2011.11.29
申请国别(地区):
NZ
年份:
2019
代理人:
摘要：
Disclosed are antibodies with low affinity to a human transferrin receptor TfR with a Kd from about 20nM to 10μM. Said antibodies may be coupled to compounds for transportation of the compounds across the blood brain barrier. Further disclosed are therapeutic uses and methods thereof of said antibodies. Further disclosed are bispecific antibodies which bind transferrin receptor with a low affinity and a second brain antigen.
