Methods to induce targeted protein degradation through bifunctional molecules

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专利权人:

Inc.;Dana-Farber Cancer Institute

发明人:

James Bradner,Dennis Buckley,Georg Winter

申请号：

US16167091

公开号：

US10669253B2

申请日:

2018.10.22

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present application provides bifunctional compounds which act as SMARCA2 and Ras protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of SMARCA2 and Ras through the use of the bifunctional compounds that link a cereblon-binding moiety to a ligand that is capable of binding to SMARCA2 or Ras. The application also provides compounds of Formula:

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中国工程科技知识中心

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http://www.ckcest.cn/home/