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METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES
专利权人:
Dana-Farber Cancer Institute; Inc.
发明人:
James Bradner,Dennis Buckley,Georg Winter
申请号:
US15148262
公开号:
US20160235731A1
申请日:
2016.05.06
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for the targeted degradation of endogenous proteins through the use of the bifunctional compounds that link a cereblon-binding moiety to a ligand that is capable of binding to the targeted protein which can be utilized in the treatment of proliferative disorders. The present application also provides methods for making compounds of the application and intermediates thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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