CHEN QI,LOPEZ OMAR D.,BENDER JOHN A.,WANG GAN,NGUYEN VAN N.,KADOW JOHN F.,MEANWELL NICHOLAS A.,BELEMA MAKONEN
申请号：
ARP120101698
公开号：
AR086389A1
申请日:
2012.05.11
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
Compounds, components and methods for the treatment of hepatitis C virus (VHC) infection. In addition, the pharmaceutical components containing these compounds and the methods of using these compounds to treat the infection of propylhch: 1. A compound with the characteristics of formula (1) or acceptable salt for drug use, wherein L is selected from the link or other members of the preparation group (2)；A and a 'are independent of the preparation group (3),If at least one of a and a is different from the other formula (4),Among them, "wavy line *" represents the bonding point of X and X, and "wavy line" represents the bonding point of L； wherein, Z is an aromatic circle composed of six members, which can optionally contain one, two or three nitrogen atoms； R2 is selected from hydrogen, tar and halogen； R3 is selected from hydrogen, Alcoxi, hequi, Ciano, halo and halocalcosi； X and X 'are independent of formula group (5),Each group is drawn with carbon atom connected with a or a and nitrogen atom connected with carbon group: n is 0, 1 or 2； s is 0, 1, 2, 3 or 4； and is selected from Y (R4) 2, Nr4, O, s (o),If n is 0 and selected from CH2, CH4, and C (R4) 2, each R4 shall be selected independently of Alcoy, hydrocarbon, arilo, Ciano, halo, halooxi, halocoqui, hydroxi, nrarb, and tioalquilo, One tar can optionally form a combined ring of three to six members, or a combined ring of four or five members and another carbon atom, or alternatively form a spiral ring of three to six members with carbon connected to it, Each ring system has one or two oxygen atomsWhen y is Nr4, R4 is different from halide, hydroxyl or nrarb； R is (nrcrd) tar, where part of the tar is replaced by a bicycle or fusion bicycle, 1. One or two independent asphalts, halogens and halotars can be selected to replace isocyclohexanes with cyclopentyl, etenilcoquilo, isocyclopentyl, oxocyclopedio or isocyclohexanes；R'es (nrcrd) asphalt, where the asphalt part of the asphalt (nrrd) asphalt can be selectiv
