OBSHCHESTVO S OGRANICHENNOJ OTVETSTVENNOSTJU "ALLOFARM"
发明人:
CHERNYSH SERGEJ IVANOVICH,Черныш Сергей Иванович (RU),GORDJA NATALIJA ALEKSANDROVNA,Гордя Наталия Александровна (RU)
申请号：
RU2010146289/15
公开号：
RU0002447896C1
申请日:
2010.11.15
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to antimicrobial agents preferentially used for treating the diseases caused by antibiotic resistant bacteria, and preventing the developing drug resistance in pathogenic microorganisms. A substance contains a purified complex of antimicrobial peptides of insects of the family Calliphoridae, which contains defensin described by the amino acid sequence Ala-Thr-Cys-Asp-Leu-Leu-Ser-Gly-Thr-Gly-Ala-Asn-Hys-Ser-Ala-Cys-Ala-Ala-Hys-Cys-Leu-Leu-Arg-Gly-Asn-Arg-Gly-Gly-Tyr-Cys-Asn-Gly-Lys-Ala-Val-Cys-Val-Cys-Arg-Asn, a proline-rich peptide described by the N-terminal amino acid sequence Phe-Val-Asp-Arg-Asn-Arg-Ile-Pro-Arg-Ser-Asn-Asn-Gly-Pro-Lys-Ile-Pro-Ile-Ile-Ser-Asn-Pro-, cecropin described by the amino acid sequence Gly-Trp-Leu-Lys-Lys-Ile-Gly-Lys-Lys-Ile-Glu-Arg-Val-Gly-Gln-Hys-Thr-Arg-Asp-Ala-Thr-Ile-Gln-Gly-Leu-Ala-Val-Ala-Gln-Gln-Ala-Ala-Asn-Val-Ala-Ala-Thr-Ala-Arg, diptericin described by the N-terminal amino acid sequence Asp-Ser-Lys-Pro-Leu-Asn-Leu-Val-Leu-Pro-Lys-Glu-Glu-Pro-Pro-Asn-Asn-Pro-Gln-Thr-Tyr-Gly-Gly-Gly-Gly-Gly-Ser-Arg-Lys-Asp-Asp-Phe-Asp-Val-Val-Leu-Gln-Gly-Ala-Gln.EFFECT: advantages of the antimicrobial agent involve the fact that bacteria develop no resistance to the presented substance if used continuously, also when used delays the developing antibiotic resistance of the bacteria and shows bactericidal action on strains of acquired drug resistance.1 cl, 6 tbl, 8 dwgИзобретение относится к антимикробным средствам, преимущественной областью его применения является лечение заболеваний, вызываемых устойчивыми к антибиотикам бактериями, и профилактика развития лекарственной устойчивости у патогенных микроорганизмов. Вещество включает очищенный комплекс антимикробных пептидов насекомых семейства Calliphoridae, в состав которого входят дефензин, характеризуемый аминокислотным сиквенсом Ala-Thr-Cys-Asp-Leu-Leu-Ser-Gly-Thr-Gly-Ala-Asn-Hys-Ser-Ala-Cys-Ala-Ala-Hys-Cys-Leu-Leu-Arg-Gly-Asn-Arg-Gly-Gly
