Described herein are a sterile drape and adapter for use with a robotic surgical system, for example, during spinal surgery. In certain embodiments, the sterile drape and adapter cover a robotic surgical arm and prevent contamination of a sterile field. The sterile drape may attached to the robotic arm via a sterile adapter that ensures the drape is tightly stretched over the tool holder and robot interface to provide a structure that provides for repeatable and rigid positioning of the sterile drape. Tightly stretching the drape over the sterile adapter and tightening the tool holder to the robotic arm using, for example, a tightening screw, reduces the likelihood of folds in the drape between the tool holder and robot interface. Thus, errors between the robot model and the actual situation because of the position of the tool holder relative to the robot interface are minimized.
