CAPSULES CONTENANT UN INHIBITEUR DE LA POMPE A PROTONS COMPRENANT DES UNITES SECONDAIRES DIFFEREMMENT STRUCTUREES PERMETTANT UNE LIBERATION RETARDEE DE L'INGREDIENT ACTIF
An oral pharmaceutical composition comprises multiple populations of at leastone of beads, pellets, tablets and granules provided in a capsule, thecomposition comprising: a first population of a pharmaceutical activecomprising a pharmaceutical active substance releasable at a first rate; apopulation of a basic substance; and a second population of a pharmaceuticalactive comprising a pharmaceutical active substance releasable at a secondrate. In another embodiment, the oral pharmaceutical composition comprisesmultiple populations of at least one of beads, pellets, tablets and granulesprovided in a capsule, the composition comprising: a population of apharmaceutical active; a population of a basic substance; a population ofenteric coated pharmaceutical active; and a population of enteric coated basicsubstance. The composition can provide multiple site specific delivery of apharmaceutical active in a rapid, delayed and/or sustained release manner intothe plasma.