CAPSULES CONTENANT UN INHIBITEUR DE LA POMPE A PROTONS COMPRENANT DES UNITES SECONDAIRES DIFFEREMMENT STRUCTUREES PERMETTANT UNE LIBERATION RETARDEE DE L'INGREDIENT ACTIF
An oral pharmaceutical composition comprises multiple populations of at least one of beads, pellets, tablets and granules provided in a capsule, the composition comprising: a first population of a pharmaceutical active comprising a pharmaceutical active substance releasable at a first rate； a population of a basic substance； and a second population of a pharmaceutical active comprising a pharmaceutical active substance releasable at a second rate. In another embodiment, the oral pharmaceutical composition comprises multiple populations of at least one of beads, pellets, tablets and granules provided in a capsule, the composition comprising: a population of a pharmaceutical active； a population of a basic substance； a population of enteric coated pharmaceutical active； and a population of enteric coated basic substance. The composition can provide multiple site specific delivery of a pharmaceutical active in a rapid, delayed and/or sustained release manner into the plasma.
