VINTONYAK, Viktor,GRAUERT, Matthias,GRUNDL, Marc,PAUTSCH, Alexander
申请号：
PE0004002017
公开号：
PE04382017A1
申请日:
2015.09.08
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Relates to compounds of formula I: wherein a and Cy are as follows.These compounds are inhibitors of cathepsin C and are related to the treatment of diseases associated with the activity of Dipeptidyl peptidase I, for example,Respiratory Diseases.The preferred compounds are the following: (1S, 2S, 4R) - N - [(1S) - 1 - 2 - cyano - [2-fluoro-4 - [1 - (3 - oxetan - yl) - 1H - spiro [isobenzofuran] - 5 piperidin 3,4 - yl] phenyl] ethyl] - 3-azabicyclo [2.2.1 heptan carboxamide] - 2 - (1S, 2S, 4R) - N - [(1S) - 1 - 2 - cyano - [2-fluoro-4 - [1 - (3 - oxetan - yl) - spiro [3H] furo [3,4-c] pyridin - 1,4 - piperidin 6 - il] phenyl] ethyl] - 3-azabicyclo [2.2.1] heptan - 2 - carboxamide among othersSe refiere a compuestos de Formula I en donde: A y Cy son como se indica a continuacion. Estos compuestos son inhibidores de catepsina C y estan relacionados con el tratamiento de enfermedades relacionadas con la actividad de dipeptidil peptidasa I, por ejemplo, enfermedades respiratorias. Entre los compuestos preferidos tenemos los siguientes: (1S,2S,4R)-N-[(1S)-1-ciano-2-[2-fluoro-4-[1-(oxetan-3-il)spiro[1H-isobenzofuran-3,4piperidin]-5-il]fenil]etil]-3-azabiciclo[2.2.1]heptan-2-carboxamida (1S,2S,4R)-N-[(1S)-1-ciano-2-[2-fluoro-4-[1-(oxetan-3-il)spiro[3H-furo[3,4-c]piridin-1,4piperidin]-6-il]fenil]etil]-3-azabiciclo[2.2.1]heptan-2-carboxamida entre otros
