Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12or R13on the A group is an amide substituent (R32) are provided. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein are capable of reducing the excessive activation of complement.本發明提供包含式I之化合物、使用方法及用於製備補體因子D抑制劑的方法,或其醫藥學上可接受之鹽或組合物,其中A基團上之R12或R13為醯胺取代基(R32)。本文所述之抑制劑靶向因子D且抑制或調節補體級聯。本文所述之因子D抑制劑能夠減少補體的過度活化。
