Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce Factor Ds ability to modulate the classical and lectin complement pathways. The inhibitors of Factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.本發明提供包含式I的化合物、使用方法及製備補體因子D抑制劑的方法,或其醫藥學上可接受之鹽或組合物。本文所述之抑制劑靶向因子D且抑制或調控替代補體路徑中之早期及必需時點的補體級聯,且降低因子D調節經典及凝集素補體路徑的能力。本文所述之因子D抑制劑能夠減少補體過度活化,補體過度活化已與某些自體免疫疾病、發炎疾病及神經退化疾病以及缺血再灌注損傷及癌症有關。
