The present disclosure relates to compositions that provide anti-anxiety relief and similar benefits and use thereof. In particular, the disclosure provides compositions containing omega-3 fatty acids concentrates, cannabanoids and L-Theanine, and the synergistic effects of these compositions provides multiple health and wellness benefits. The disclosure further provides the use of these compositions in addressing multiple indications for health and wellness, including but not limited to, sleeplessness, anxiety, pain associated with general inflammation, drug addiction, brain injury, and/or alpha wave brain disorder.