DANIEL TO,MOHAMMED A. AZAD,RAJESH DAVE,ECEVIT A. BILGILI,CATHARINA KNIEKE
申请号：
ARP130104150
公开号：
AR093449A1
申请日:
2013.11.12
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
A composite particle includes a core having at least one carrier, a fluid substance layer on the core surface, and an outer layer composed of nanoparticles of a substance emitted from at least one molding material. A process for the production of composite particles includes the phase of dry coating of particles with a fluid material, preparation for nanoparticle suspension from a material that can be dispersed through a matrix forming material,This process and product provides fast dissolving composite particles that can be used to manage insoluble ingestion materials in an appropriate dose form. This procedure reduces or prevents aggregation.A use the appropriate dosage form. This procedure reduces or prevents particle aggregation during the manufacture of synthetic particles, in order to manage and rapidly redistribute nanoparticles in materials that can be ingested in one dose form.And an outer layer including a nanoparticle of a material that can be inhaled and at least one molding material. 13. Claim 2: composite particle conforming to claim 1, characterized in that the particle is a particle with an average particle size of about 20 mm to 200 mm. 3. Characteristic 3: composite particle conforming to characteristic 1, which is composed of starch, lactose, sugar, cellulose, cellulose and their mixture. Claim 4: the composite particle of claim 1,which also comprises a layer of fluidizing material located between the core and the outer layer. Claim 5: The composite particle according to claim 4, characterized in that the fluidizing material is selected from silica, alumina, titanium, carbon black, aluminum and calcium silicate, calcium silicate, magnesium silicate, potassium silicate, silicate sodium, sodium aluminosilicate, calcium and sodium aluminosilicate, tricalcium silicate, silica airgel, talc, iron oxide, other metal oxides and mixtures thereof. Claim 12: The composite particle according to claim 12,It is characterized in that at least one polymer is sele
