Robert Davidson Binns,John William Patrick Kinmont
申请号：
GB201618863
公开号：
GB2552392A
申请日:
2016.11.08
申请国别(地区):
GB
年份:
2018
代理人:
摘要：
A liquid-dispersible powder comprising nanoscale grains of a matrix material composed of one or more biocompatible oxides, in particular Al2O3 or alumina, in which the matrix contains a plurality of isolated nanoparticles wherein each nanoparticle comprises a magnetic core selected from one or more of Fe or an alloy of Fe/Co, is provided. Preferably, the core is surrounded by a biocompatible shell of iron oxide forming Fe@FeO nanoparticles. A method of production of a liquid-dispersible powder is also outlined comprising the steps of: (a) providing nanoparticles prepared under ultra-high vacuum (UHV) gas phase conditions, wherein each magnetic nanoparticles comprises a magnetic core selected from one or more of Fe or an alloy of Fe/Co； (b) co-depositing a plurality of nanoparticles within a matrix material composed of one or more biocompatible oxides under UHV gas phase conditions； (c) grinding the film to a fine powder comprising grains of groups of matrix isolated nanoparticles. Preferably the liquid-dispersible powder is for use in the magnetic nanoparticle hyperthermia (MNH) treatment of tumours. A composition for the magnetic nanoparticle hyperthermia (MNH) treatment of tumours comprising nanoscale grains of a matrix material containing one or more isolated nanoparticles, and a method of reducing the agglomeration of nanoparticles in a liquid, the method comprising isolating a plurality of nanoparticles in nanoscale grains of a matrix material composed of one or more biocompatible oxides are also outlined.
