CARAVATTI, GIORGIO,FAIRHURST, ROBIN ALEC,FURET, PASCAL,STAUFFER, FREDERIC,SEILER, FRANK HANS,RUEEGER, HEINRICH,MCCARTHY, CLIVE
申请号：
PE0012912014
公开号：
PE24562014A1
申请日:
2013.02.22
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Referring to a oxazolidin - 2 - One compound of formula (i), wherein R1 is a Group (a) or (b), A1A is H or CH3 d is deuterium R2 is H, CH3, CH2OH, ch2och3, among others R3 is h R4 is CH2OH, h, CH3, between Other R5 is H, CH3, CH2OH, among others.Preferred compounds are: (S) - 3 - (2 - amino - 4 - 2 (IL - 4 - trifluoromethyl - [4,5] bipirimidinil - 6 - yl) - 4 - methyl - 2 - One oxazolidin -, (S) - 3 - (2 - amino - 2 - (- 4 - il - 4 - trifluoromethyl - [4,5] bipirimidinil - yl) - 4 - 6 - Hydroxymethyl - 5,5 - dimethyl - 2 - oxazolidin Ona, among others. It also relates to a Pharmaceutical composition.These compounds act as inhibitors of the PI3K (phosphatidylinositol 3-kinase)REFERIDA A UN COMPUESTO OXAZOLIDIN-2-ONA DE FORMULA (I), DONDE R1 ES UN GRUPO (a) O (b) R1a ES H O CH3 D ES DEUTERIO R2 ES H, CH3, CH2OH, CH2OCH3, ENTRE OTROS R3 ES H R4 ES H, CH2OH, CH3, ENTRE OTROS R5 ES H, CH3, CH2OH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (S)-3-(2-AMINO-2-MORFOLIN-4-IL-4-TRIFLUOROMETIL-[4,5]BIPIRIMIDINIL-6-IL)-4-METIL-OXAZOLIDIN-2-ONA, (S)-3-(2-AMINO-2-MORFOLIN-4-IL-4-TRIFLUOROMETIL-[4,5]BIPIRIMIDINIL-6-IL)-4-HIDROXIMETIL-5,5-DIMETIL-OXAZOLIDIN-2-ONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS ACTUAN COMO INHIBIDORES DE LA PI3K (FOSFATIDILINOSITOL-3-QUINASA)
