C(10) ethyl ester and C(10) cyclopropyl ester substituted taxanes

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专利权人:

Phong Vu

发明人:

Phong Vu,Robert A. Holton

申请号：

US12409884

公开号：

US08242166B2

申请日:

2009.03.24

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Taxanes having an ethyl ester or cyclopropyl ester substituent at C(10), a keto substituent at C(9), a hydroxy substituent at C(7), a thienyl substituent at C(3′) and a cyclobutyloxycarbamate or cyclopentyloxycarbamate substituent at C(3′), pharmaceutical compositions comprising such taxanes, methods of treatment and administration, and methods of preparation of medicaments comprising the taxanes.

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