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ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ТАКСОИДОВ
专利权人:
КАДИЛА ФАРМАСЬЮТИКАЛЗ ЛИМИТЕД (IT)
发明人:
ХАМАР Бакулеш Мафатлал (IN),ГОГИА Ашиш Премкумар (IN),ЛАДДХХА Риту Нитин (IN),ХАН Имран Ахмед (IN),ПАТРАВАЛЕ Вандана Бхарат (IN),МОДИ Индравадан Амбалал (IN)
申请号:
RU2013126259/15
公开号:
RU2013126259A
申请日:
2011.11.05
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A stable oral pharmaceutical composition taxoid with improved solubility and bioavailability for administration to mammals substantially consisting of taxoids, solubilizers, stabilizing agents, surfactants (th) substance (s), solvent (s) and an oil, wherein the ratio solubilizer: taxoid and stabilizing agent: taxoid range from 3 to 150 and from 0.5 to 3.3 sootvetstvenno.2. A stable oral pharmaceutical composition according to claim 1, wherein the taxoid concentration varies from 0.1 to 10% by masse.3. A stable oral pharmaceutical composition according to claim 1, wherein the taxoid concentration preferably ranges from 0.4 to 6% by masse.4. A stable oral pharmaceutical composition according to claim 1, wherein the taxoid is selected from paclitaxel or docetaxel, or derivatives thereof, or their pharmaceutically acceptable soley.5. A stable oral pharmaceutical composition according to claim 1, wherein the surfactant is selected from caprylic / caproyl macrogol glycerides, alpha-tocopheryl polyethylene glycol 1000 succinate, polysorbate and PEG hydrogenated castor masla.6. A stable oral pharmaceutical composition according to claim 1, wherein the concentration of surfactant varies from 10 to 60% by masse.7. A stable oral pharmaceutical composition according to claim 1, wherein the solvent is selected from propylene glycol and ethyl spirta.8. A stable oral pharmaceutical composition according to claim 1, wherein the concentration of surfactant varies from 5 to 25% by masse.9. A stable oral pharmaceutical composition according to claim 1, wherein the oil is selected from: 1) Fatty triglycerides1. Стабильная пероральная фармацевтическая композиция таксоида с улучшенной растворимостью и биодоступностью для введения млекопитающим по существу состоящая из таксоидов, солюбилизатора, стабилизирующего агента, поверхностно-активных(ого) веществ(а), растворителя(ей) и масла, где соотношение солюбилизатор : таксоид и стабилизирующий агент : таксоид варьируют от 3 до 150 и от 0,
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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