The present invention is directed to hemostatic compositions comprising at least partially integrated agglomerated ORC fibers, fibrinogen, and thrombin and methods of forming a powdered hemostatic composition, comprising the steps of: forming a suspension of a mixture comprising particles of fibrinogen, thrombin, ORC fibers in a non-aqueous low boiling solvent； spraying the suspension through a nozzle onto a substrate, allowing the non-aqueous solvent to evaporate； separating from the substrate and sieving the composition.
