METHOD FOR SCREENING COMPONENT WHICH PREVENTS DEGRADATION OF COLLAGEN STRUCTURE BY LOW-OXYGEN CONDITION AND/OR AGING, USING BINDING DEGREE OF COLLAGEN FIBERS AS INDICATOR
PROBLEM TO BE SOLVED: To provide a new technique for screening a component which is effective for preventing degradation of a collagen structure in a living body.SOLUTION: The present invention relates to a method for screening a component which prevents degradation of a collagen structure by a low-oxygen condition and/or aging, the method using, as an indicator, an increase reduction effect of the binding degree of collagen fibers when an inspection target component is added to a collagen-containing composition with cells dispersed and is incubated under a low-oxygen condition.SELECTED DRAWING: Figure 4COPYRIGHT: (C)2020,JPO&INPIT【課題】生体におけるコラーゲン構造の悪化を抑制する効果のある成分をスクリーニングするための新たな技術の提供。【解決手段】細胞を分散させたコラーゲン含有組成物に、被検成分を添加して、低酸素条件でインキュベーションしたときの、コラーゲン線維の結束度の上昇低減効果を指標とすることを特徴とする、低酸素条件及び／又は加齢による、コラーゲン構造の悪化を抑制する成分のスクリーニング方法。【選択図】図４
