ЛИХТЕР Джей (US),ФОЛЛЬРАТ Бенедикт (US),ТРЭММЕЛ Эндрю М. (US),ДЮРОН Сергио Г. (US),ПЬЮ Фабрис (US),ДЕЛЛАМЭРИ Луис А. (US),Е Цян (US),ЛЕБЕЛ Карл (US),СКАЙФ Майкл Кристофер (US),ХАРРИС Джеффри П. (US)
申请号：
RU2012139802/15
公开号：
RU2012139802A
申请日:
2012.09.18
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A pharmaceutical composition suitable for use in the treatment of ear diseases by administration to intratimpanicheskogo window membrane of the cochlea or near comprising ear acceptable aqueous thermoreversible gel and the anti-inflammatory corticosteroid in a multiparticulate form, so sustained release of the anti-inflammatory corticosteroid window membrane of the cochlea in the cochlea of the inner ear occur for at least 5 days after a single vvedeniya.2. The composition of claim 1 having a pH between about 7.0 and about 8,0.3. A composition according to claim 1, suitable for use in the treatment of Menieres disease, made so as to provide sustained release of a therapeutically effective amount of dexamethasone, methylprednisolone, or prednisolone window membrane of the cochlea of the inner ear to the cochlea for at least 5 days, wherein the composition comprises : between 1 mg / ml and 70 mg / ml of dexamethasone, methylprednisolone, prednisolone, or pharmaceutically acceptable prodrug or salt thereof in a plurality of particles, between 16% and 21% by weight of the copolymer polioksieti ene-polyoxypropylene wherein the pharmaceutical composition has an osmolality between 250 and 320 mOsm / kg, for acceptable perilymph, 50th cfu microbiological agents per gram kompozitsii.4. A composition according to claim 1, suitable for use in the treatment of sudden sensorineural hearing loss, composed so as to provide sustained release of a therapeutically effective amount of dexamethasone, methylprednisolone, or prednisolone window membrane of the cochlea of the inner ear to the cochlea for at varied1. Фармацевтическая композиция, пригодная для применения при лечении ушных болезней путем интратимпанического введения на мембрану окна улитки уха или около нее, включающая приемлемый для уха термообратимый водный гель и противовоспалительный кортикостероид в виде множества частиц, так что пролонгированное высвобождение противовоспалительного кортикостероида через мембра
