1. Inhibitors from helix-[1.3]-oxalic acid and helix-[1.4]-oxalic acid, Bac 1 and/or Bac2； pharmacological synthesis； preparatory procedures； and uses for the treatment and/or prevention of Alzheimer's disease and diabetes.

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专利权人:

F.HOFFMANN LA ROCHE AG

发明人:

WOSTL, WOLFGANG,NARQUIZIAN, ROBERT,PINARD, EMMANUEL

申请号：

CL2013003372

公开号：

CL2013003372A1

申请日:

2013.11.25

申请国别(地区):

CL

年份:

2014

代理人:

摘要：

The present invention provides spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.COMPUESTOS DERIVADOS DE ESPIRO-[1,3]-OXACINAS Y ESPIRO-[1,4]-OXACEPINAS, INHIBIDORES DE BACE1 Y/O BACE2； COMPOSICION FARMACEUTICA； PROCEDIMIENTO PARA PREPARARLOS； Y SU USO EN EL TRATAMIENTO Y/O LA PROFILAXIS DE LA ENFERMEDAD DE ALZHEIMER Y DIABETES.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/