Application of plasminogen in the preparation of medicine for treating and/or eliminating cardiovascular disease, particularly cardiovascular disease caused by diabetes mellitus. Provided is a preparation used for preventing and/or treating cardiovascular disease, comprising an effective dose of plasminogen.本發明涉及纖溶酶原在治療和/或消除心血管病,尤其是由糖尿病引起的心血管病方面的作用,進而為治療不同類型的心血管病,尤其是由糖尿病引起的心血管病及其相關病症提供全新的治療策略。