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Process for the preparation of pemetrexed and lysin salt thereof
专利权人:
Berlin-Chemie AG
发明人:
Bonaccorsi, Fabrizio,Calvani, Federico,Pasqui, Franco
申请号:
AU2013301156
公开号:
AU2013301156B2
申请日:
2013.08.08
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
The present invention refers to a process for the synthesis of pemetrexed and salts thereof, in particular to a lysine salt thereof, to said salt as such and to pharmaceutical compositions that comprise the same. Furthermore, the present disclosure also relates to a crystalline form of the synthesis intermediate pemetrexed diethyl ether and a crystalline form of the pemetrexed lysine salt.
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