Process for the preparation of pemetrexed and lysin salt thereof

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专利权人:

Berlin-Chemie AG

发明人:

Bonaccorsi, Fabrizio,Calvani, Federico,Pasqui, Franco

申请号：

AU2013301156

公开号：

AU2013301156B2

申请日:

2013.08.08

申请国别(地区):

AU

年份:

2017

代理人:

摘要：

The present invention refers to a process for the synthesis of pemetrexed and salts thereof, in particular to a lysine salt thereof, to said salt as such and to pharmaceutical compositions that comprise the same. Furthermore, the present disclosure also relates to a crystalline form of the synthesis intermediate pemetrexed diethyl ether and a crystalline form of the pemetrexed lysine salt.

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