PROBLEM TO BE SOLVED: To provide an ointment preparation type pharmaceutical composition which can suppress fluctuation of drug concentration in a horny layer after a long time from administration and can maintain drug concentration in the horny layer.SOLUTION: There is disclosed an ointment preparation type pharmaceutical composition which contains: a hydrophobic ointment base a luliconazole compound represented by general formula (1) and N-alkyl-2-pyrrolidone.COPYRIGHT: (C)2014,JPO&INPIT【課題】投与後長時間経過後の角層内薬剤濃度の変動を抑制し、角層内薬物濃度を維持できる軟膏製剤型医薬組成物の提供。【解決手段】疎水性軟膏基剤、一般式(1)に表される化合物ルリコナゾール、及びN-アルキル-2-ピロリドンを含有する軟膏製剤型医薬組成物。【選択図】なし
