TARGETING THE CBM SIGNALOSOME COMPLEX INDUCES REGULATORY T CELLS TO INFLAME THE TUMOR MICROENVIRONMENT

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专利权人:

THE GENERAL HOSPITAL CORPORATION

发明人:

MEMPEL, Thorsten R.,DI PILATO, Mauro

申请号：

SG11202006200R

公开号：

SG11202006200RA

申请日:

2018.12.28

申请国别(地区):

SG

年份:

2020

代理人:

摘要：

Described herein are methods and compositions for the treatment of cancer. Aspects include administering (1) an agent that inhibits activity of a CBM signalosome complex, or (2) a cell engineered to have reduced CBM signalosome complex levels to a subject having cancer. In various embodiment, the methods further comprise administering second therapeutic, for example, a checkpoint inhibitor or anti-cancer therapy, to the subject.

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